ISMB99 - Tutorial 2

 


Bioinformatics and Molecular Biology


Douglas Brutlag

This tutorial will present an overview of molecular biology; the problems it addresses and the methods it uses. We will present the flow of genetic information from the genome to the phenotype (biological characteristics) of an organism. We will present an overview of the molecular steps that nature uses to replicate and repair DNA; regulate expression of genes; process and translate messenger RNAs; modify and target proteins in the cell; integrate and regulate metabolism. We will describe, and give specific examples, where molecular processes can be addressed computationally. We will emphasize the need for multiple representations of many steps (heuristic, rule-based, probabilistic, information based, graph theoretic etc.). We will present a view of molecular biology as an information science. We will parallel the molecular and bioinformatic approaches to biological questions and describe the synergisms that result from using both.

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