ISMB99 - Tutorial 5

The biology and bioinformatics of regulatory regions in genomes Thomas Werner The tutorial is meant as an introduction to the problems of in silico analysis of regulatory DNA regions for both computer scientists lacking profound biological background as well as for biologists interested in the basic principles of regulatory sequence analysis algorithms. It is intended for a rather general interdisciplinary audience and its main focus will be on eukaryotic transcriptional regulatory regions. However, most of the principles are also valid for prokaryotic regulatory regions. References: Werner, T. Identification and characterization of promoters in eukaryotic DNA sequences. Mammalian Genome, in press. Audic, S., Claverie, J., M. Visualizing the competitive recognition of TATA-boxes in vertebrate promoters. Trends in Genetics 14, 10-11, 1998. Lavorgna, G., Boncinelli, E., Wagner, A., Werner, T. Detection of potential target genes in silico?. Trends in Genetics 14, 375-376, 1998. Fickett, J., W., Hatzigeorgiou, A.,C. Eukaryotic promoter recognition. Genome Research 7, 861-878, 1997. Arnone, M., I., Davidson, E., H. The hardwiring of development: organization and function of genomic regulatory systems. Development 124, 1851-1864, 1997.

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