ISMB99
Exploiting Protein Structure in the Post-genome Era

Michael J. E. Sternberg (1)
Paul A. Bates (1)
Lawrence A. Kelley (1)
Robert M. MacCallum (1)
Arne Müller
Stephen Muggleton (2)
Marcel Turcotte (1)

(1) Bimolecular Modelling Laboratory
Imperial Cancer Research Fund
44 Lincoln's Inn Fields
London WC2A 3PX, England

http://www.icnet.uk/bmm

(2) Department of Computer Science
University of York,
York, Y01 5DD, England

Abstract: Intelligent Systems for Molecular Biology 99

Diverse and innovative computational approaches are required to exploit the information encoded in protein structures so the knowledge can be used to interpret the explosion of genome sequence data. In particular algorithms are required to predict protein structure and function from sequence. To illustrate the computational challenges, the following topics currently being considered in our laboratory will be described:

• the need to encapsulate expert knowledge in protein structure prediction
• the strategy to assign protein folds to genome sequences
• the detection of remote protein homologues using information from protein
  structures
• the use of inductive logic programming, a branch of machine leaning, to
  identify principles of protein folding.
  

back to Schedule

-> ISMB 99