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Computational Epigenetics Seminar (SS 2010)


  • 2010-10-11 The schedule for October 12 is: 10:15 to 12:15 and 13:00 to 16:00.
  • 2010-10-11 The schedule for October 13 is: 09:15 to 12:15 and 14:00 to 16:00.
  • 2010-04-19 The date for the introductory meeting has changed. It will take place on Monday, April 26.

General information

Lead by Thomas Lengauer
Assistants Yassen Assenov, Lars Feuerbach, Konstantin Halachev
Language English

Important dates

Initial meeting Monday, April 26, 2010 at 12:00 in Campus E1 4 (MPI building), Room 024
Review submission before Friday, October 1, 2010, 23:59
Presentations October 12 and 13, 2010 in Campus E1 4 (MPI building), Room 021


Epigenetic research aims to understand heritable gene regulation that is not directly encoded in the DNA sequence. Epigenetic mechanisms such as DNA methylation and histone modifications modulate the packaging of the DNA in the nucleus and thereby influence gene expression. Various bioinformatic challenges arise from the analysis of epigenetic data, and computational methods have already played a role in solving important epigenetic problems. In this seminar, we introduce the basic concepts of epigenetics and we summarize relevant computational and bioinformatic work performed in this area.


This is an integrated seminar that combines Master Seminar and Proseminar topics. It can be attended by students at the Bachelor, as well as at the Master level in Bioinformatics and Computer Science. The language is English. The seminar is going to take place as a two-day Blockseminar on October 12 and 13. If you consider participating in the seminar, you need to attend the initial meeting on Thursday, April 22.

For a successful completion, every participant must:

  1. Select one of the topics listed in the section below. Topics will be distributed during the initial meeting on April 22.
  2. Write a short review on the selected topic in English. Bachelor students must summarize the results of the relevant publications in 2 to 3 pages. Master students must also comment on the advantages and the shortcomings of the methodologies, their reviews must be between 5 and 7 pages long. The deadline for submitting the reviews is Friday, October 1. Every participant can (and is encouraged to) schedule a meeting with one of the assistants in the seminar, in order to discuss the review draft before submission.
  3. Prepare and give a presentation on the selected topic in English. Every presentation is followed by a short discussion. For Bachelor students, the presentations must be no longer than 30 minutes; for Master students no longer than 40 minutes. Discussions after presentations by Bachelor students can be held in German. Every participant can (and is encouraged to) schedule a meeting with one of the assistants in the seminar, in order to discuss the presentation slides before the meeting.
  4. Actively participate in the discussions after the presentations. Attendance during the whole seminar is required.

Presentation guidelines

Prof. Lengauer has written guidelines for scientific presentations. They are available in English (Word  PDF) and in German (Word  PDF). They are really helpful; please read them carefully before you start working on our presentation.

Topics and registration

The topics that are going to be discussed in the seminar are listed below. Click on a topic title to see a short description.

Please note that the number of participants is limited to 20. If you would like to attend the seminar, send an email with subject Computational Epigenetics to Yassen, and include the following information:


Publications related to each topic are available in the password protected area.