Methods for Population Genetics
Methods for Population Genetics - Tobias Marschall
This is the old page of the MFPG lecture in winter 2014/15! Please visit the current one.
- Spezialvorlesung (2+1) with exercises (5 credits)
- Lecture time: Tuesdays 12:15-13:45 (FIRST LECTURE: October 28)
- Place: Room 007, Campus E2.1
- Exercise: biweekly, time will be determined in first lecture.
- Oral exam at the beginning of semester break.
- Re-exam at the end of semester break.
Population Genetics studies the distribution of genetic information across populations under varying conditions. This lecture provides the necessary methods to answer questions such as: Is there evidence for selection pressure on a certain gene? How can ancient migration patterns be retraced based on genetic information? How can quantitative traits such as disease susceptibility be attributed to genetic loci? We first cover basic concepts like the Hardy-Weinberg principle, genetic drift, and linkage disequilibrium. Then, we proceed to studying selection pressure, population subdivision, and quantitative traits. Towards the end of this course, we will cover haplotype phasing and imputation of missing genotype data as well as the interplay of population genetics and next-generation sequencing.
If you want to take this course, you should subscribe to the mailing list. Important announcements will be send to this list. Also, it can serve as a platform for discussing questions related to the course.
The main source for the course will be the text book Principles of Population Genetics by Hartl and Clark.
- Principles of Population Genetics by Daniel Hartl and Andrew Clark.
Furthermore, the following books also cover many of the topics that we will discuss:
- Population Genetics -- A Concise Guide by John Gillespie.
- Population Genetics by Matthew Hamilton.
Lecture slides and supplementary course material will be available here: password protected area.